Marmol and Gregg have each pitched two games in a row. That could be a problem, given that Randy Wells is unlikely to go much more than five innings. Why not just accept before the game that no matter what happens, Wells will stay in for five, Guzman will pitch the sixth and the seventh, and, I don’t know, Cotts will pitch the eighth and, if necessary, ninth? There’s potential for disaster there, but you would keep the better pitches in the pen (Heilman, Marmol and Gregg) fresh, and I don’t know if you significantly hurt your odds of winning. You can always use one of those three to close, too, if the Cubs are up at the end.